Released on = August 14, 2006, 4:56 pm

Press Release Author = Debra Thai

Industry = Biotech

Press Release Summary = AnaSpec has been providing b-Amyloid peptides to leading
Alzheimer's researchers for almost 10 years. As interest in amyloid peptides
continues to grow, AnaSpec has developed an extensive selection of catalog amyloid
peptides to match that interest. Equipped with expertise in both peptide synthesis
and detection technologies, AnaSpec presents one of the world's most comprehensive
collection of amyloid peptides.

Press Release Body = ß-Amyloid (Aß) peptides, made up of long, insoluble ordered
fibers, are glycoproteins deposited extracellularly in tissues in amyloidosis. These
peptides are generated as cleavage products from the membrane protein, Amyloid
Precursor Protein (APP) by two proteases, b-secretase and g-secretase. Aßs are
amphiphilic peptides with a hydrophilic N-terminal domain (residues 1 to 28) and a
hydrophobic C-terminal (residues 29 to 40), the latter corresponding to a part of
the transmembrane domain of APP. These insoluble amyloid deposits found in
Alzheimer's diseased brains have been the subject of increased interest for
Alzheimer's treatment (reviewed in 1, 2).

The AnaSpec collection includes:
· Aßs of various lengths
· Amino acid-substituted Aßs
· Dye-labeled Aßs
· Biotin-labeled Aßs
· TFA salt forms (Standard form, unless otherwise specified)
· Sodium forms
· HCl forms
· iAb5p and other-Aß inhibitors
· Humanins
· Secretase fluorescent resonance energy transfer (FRET) substrates and
inhibitors
· APP Fragments

Full listing of amyloid peptides available at our website.

References:
1. Selkoe DJ. Nature 399, A23 (1999).
2. Suh, Y-H. and F. Checler. Pharma. Rev. 54, 469 (2002).



Web Site = http://www.anaspec.com

Contact Details = 2149 O\'Toole Ave.
San Jose, CA 95131
408-452-5055
408-452-5059 fax
info@anaspec.com
service@anaspec.com
marketing@anaspec.com